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Serotonin transporter polymorphisms affect human blood glucose control.

Yamakawa M, Fukushima A, Sakuma K, Yanagisawa Y, Kagawa Y

High Technology Research Center, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado, Saitama 250-0288, Japan.

We measured the effect of nutritional intervention on clinical data, including fasting blood glucose (FBG), and their association with polymorphisms of the serotonin transporter-linked polymorphic region (5-HTTLPR) which might affect adherence. Enrolled in the intervention program were 264 Japanese women not on medication for diabetes, hypercholesterolemia or hypertension. The 5-HTTLPR allele (S and L) frequencies among the subjects differed markedly from those of Caucasians: SS (n = 183), LS (n = 69), and LL (n = 12). The decrease in FBG (DeltaFBG) from the beginning to the end of the program (11 weeks; short-term study), and DeltaFBG from the beginning to a follow-up check performed between 2002 and 2004 (average of 23 years later; long-term study) was calculated. The SS homozygotes of 5-HTTLPR showed larger DeltaFBG (P = 0.01 and P < 0.0001 in the short- and long-term studies, respectively) than DeltaFBG with other genotypes.

Published 1 August 2005 in Biochem Biophys Res Commun, 334(4): 1165-71.
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