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Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity.

Huang XF, Zavitsanou K, Huang X, Yu Y, Wang H, Chen F, Lawrence AJ, Deng C

Department of Biomedical Science, University of Wollongong, NSW 2522, Australia.

This study examined the density of dopamine transporter (DAT) and D2 receptors in the brains of chronic high-fat diet-induced obese (cDIO), obese-resistant (cDR) and low-fat-fed (LF) control mice. Significantly decreased DAT densities were observed in cDR mice compared to cDIO and LF mice, primarily in the nucleus accumbens, striatal and hypothalamic regions. D2 receptor density was significantly lower in the rostral part of caudate putamen in cDIO mice compared to cDR and LF mice.

Published 20 November 2006 in Behav Brain Res, 175(2): 415-9.
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