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Growth hormone and respiratory compromise in Prader-Willi Syndrome.

Wilson SS, Cotterill AM, Harris MA

Department of Respiratory and Sleep Medicine, Mater Children's Hospital, South Brisbane, Australia.

Recombinant human growth hormone (rhGH) therapy in Prader-Willi syndrome (PWS) causes increased basal metabolic rate and oxygen consumption, and hence increased ventilatory load. The case of an adolescent with PWS who experienced respiratory deterioration with an increase in rhGH and improvement with cessation of therapy is reported.

Published 22 March 2006 in Arch Dis Child, 91(4): 349-50.
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