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Effect of surgically removing subcutaneous fat by abdominoplasty on leptin concentrations and insulin sensitivity.

Martínez-Abundis E, Molina-Villa CA, González-Ortiz M, Robles-Cervantes JA, Saucedo-Ortiz JA

Medical Research Unit in Clinical Epidemiology, Mexican Institute of Social Security, Guadalajara, Mexico. uiec@prodigy.net.mx

The aim of this study was to identify the effect of surgically removing subcutaneous fat by abdominoplasty on leptin concentrations and insulin sensitivity. An open clinical trial with a noninterventional parallel group was carried out in 12 obese women. After randomization, 6 volunteers were selected for abdominoplasty, and the other 6 women were considered as the noninterventional group. A metabolic profile, including leptin concentrations, and insulin tolerance test to assess insulin sensitivity were performed on all volunteers before intervention or nonintervention and 40-50 days afterward. A significant reduction in body mass index (30.7 +/- 0.9 versus 29.6 +/- 0.7 kg/m; P = 0.02) and in leptin concentrations (41.3 +/- 10.6 versus 32.0 +/- 10.2 ng/mL; P = 0.02) was observed after abdominoplasty. Insulin sensitivity did not change after intervention. In conclusion, surgically removing subcutaneous fat by abdominoplasty decreased leptin concentrations, with no change in insulin sensitivity.

Published 6 April 2007 in Ann Plast Surg, 58(4): 416-9.
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