Obesity Research Today is a free monthly online journal that collates and summarizes the latest research about Obesity, including details on health, diet, prevention, exercise. | ||||||||
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Expression of TNF-alpha protein in omental and subcutaneous adipose tissue in obesity.Cao YL, Hu CZ, Meng X, Wang DF, Zhang J Department of Endocrinology, First Affiliated Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, Liaoning 110001, China. BACKGROUND: During the last several years the role of adipose tissue in contributing to obesity-associated cardiovascular and metabolic risk has gained much attention. AIM: To examine the expression of TNF-alpha protein in omental and subcutaneous adipose tissue in correlation with plasma PAI-1 and other clinical parameters in obesity subjects. MATERIAL AND METHODS: Paired biopsies of omental and subcutaneous fat were collected during surgery in 32 obesity subjects. The expression of TNF-alpha protein in omental and subcutaneous fat was quantified by using Western blot method, and correlations with plasma PAI-1, homeostasis model assessment insulin resistance (HOMA-IR) and lipid were investigated. RESULTS: TNF-alpha protein expression was higher in omental than in subcutaneous adipose tissue (P<0.01). Significant positive linear correlations were found between TNF-alpha protein in omental adipose tissue and plasma PAI-1 in obesity subjects. TNF-alpha protein in omental fat was positively associated with HOMA-IR, triglycerides and negatively with HDL-cholesterol. CONCLUSION: TNF-alpha expression in omental adipose tissue could play a key role in contributing to cardiovascular risk in central obesity subjects. Published 1 February 2008 in Diabetes Res Clin Pract, 79(2): 214-9.
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