Obesity Research Today is a free monthly online journal that collates and summarizes the latest research about Obesity, including details on health, diet, prevention, exercise.

A putative role for apelin in the etiology of obesity.

Rayalam S, Della-Fera MA, Krieg PA, Cox CM, Robins A, Baile CA

Department of Animal & Dairy Science, University of Georgia, 444 Animal Science Complex, Athens, GA 30602-2771, USA.

Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.

Published 4 March 2008 in Biochem Biophys Res Commun, 368(3): 815-9.
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